Comments on Oral Absorbtion From Some Experts

"Medical Procedures to obtain proper concentration of drugs or nutrients to be beneficial to the individual must be administered every 3 to 4 hours. " ne larger or mega dose results in excessive or overdosing with taxation of the kidney to excrete. Comparative data--100 mg. consumed as a tablet translates to a stabilized 8.3 mg. blood concentrate. 100 mg. consumed in 4 equal doses translates to a stable 78.6 mg. blood concentrate. Smaller doses administered with more frequency seem to raise blood concentrate. "Oral liquid or spray is far superior, showing higher concentration with lower more frequent dosages. Avoidance of gastrointestinal system is preferred when spray or sublingual is available."

"Drugs or nutrients administered in solution are generally absorbed much more rapidly than those administered in solid form, since the process of dissolution is not required. "A liquid preparation is more convenient to administer to those who are unable to swallow tablets or capsules or have difficulty swallowing them. In addition, solutions have the advantage over solid dosage forms in that they do not have the delay characteristics of solid dosage forms but are presented to the body in a form most conducive for absorption directly into the bloodstream upon administration. "The mucosal lining of the mouth is superior for the passage of a drug or nutrient and involves the same principles of drug absorption as described earlier, with the lipid/water distribution co-efficient being a prime factor in the absorption capability of a drug or nutrient substance."

"Current drugs, good as many of them are, are far from perfect. All carry the risk of side effects. In part, this risk derives from the way drugs work in the body, a medical specialty known as Pharmacokinetics. A regimen of pills causes an irregular of medicine in the body, which can be plotted as a series of 'peaks and valleys'. At the peak, when a pill first dissolves, too much drug is present; at the valley, as time goes on, there is too little drug. The peak signals an increased risk of side effects; the valley, less benefit from the drug. In essence, the new drug delivery systems seek to flatten the Pharmacokinetic graph. By releasing a steady, continuous flow of medicine, the new systems are designed to lower the peaks and ideally to produce better results. "In addition, because these new delivery systems do away with pills, consumers should find them more convenient. Convenience, it is hoped, will mean less medication left at home, forgotten at bedtime, or unused "because it didn't seem to be working.'"

"Absorption from all sites of administration is dependent upon drug solubility. Drugs given in solution are more rapidly absorbed than those given in solid form. "Absorption from the buccal mucosa (mouth) is rapid. A higher concentration of the drug or nutrient in the blood is achieved than by absorption lower in the alimentary tract because metabolism of drugs or nutrients as a result of passage through the liver is avoided and because the drug or nutrient is not subjected to possible destruction by the gastrointestinal secretions or to formation of complexes with foods. "The mucosal lining of the mouth to the passage of drugs or nutrients, and their absorption through the buccal mucosa involves the same principles for most epithelial membranes."

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